Neurodegenerative diseases and therapeutic strategies using iron chelators
نویسندگان
چکیده
منابع مشابه
Neurodegenerative diseases and therapeutic strategies using iron chelators.
This review will summarise the current state of our knowledge concerning the involvement of iron in various neurological diseases and the potential of therapy with iron chelators to retard the progression of the disease. We first discuss briefly the role of metal ions in brain function before outlining the way by which transition metal ions, such as iron and copper, can initiate neurodegenerati...
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A number of iron-chelating agents are currently being considered as orally active alternatives to desferrioxamine (DFO), the therapeutic agent for the treatment of body iron overload that is available at present. These include bidentate hydroxypyridinones (HPO), tridentate desferrithiocin (DFT) analogues and hexadentate aminocarboxylate (HBED) chelators. All chelating agents have the potential ...
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ژورنال
عنوان ژورنال: Journal of Trace Elements in Medicine and Biology
سال: 2015
ISSN: 0946-672X
DOI: 10.1016/j.jtemb.2014.12.012